Colloidal silica (medicinal excipients) summary list, one read colloidal silica

Created on 2024.12.27
Colloidal silica
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Colloidal Silicon Dioxide
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Colloidal silica (medicinal excipients)
同义词 (Chinese) - Synonym (English)
Micropowdered Silica Gel
Synonyms: Words with similar meanings
Aerosil; colloidal silica; fumed silica; fumed silicon dioxide; hochdisperses silicum dioxid; SAS; silica colloidalis anhydrica; silica sol; silicic anhydride; silicon dioxide colloidal; silicon dioxide fumed; synthetic amorphous silica; Wacker HDK
Chemical Name
Silica
CAS Registry Number
7631-86-9 is translated into English as "Silica"
Molecular Formula
SiO₂ translates to "silicon dioxide" in English.
Molecular Weight
Sixty point zero eight
结构式
None
Classification
Viscosity Increasing Agent; Suspending Agent
Uses
Widely used in pharmaceuticals, cosmetics, and food. It can improve the fluidity of dry powder (such as tabletting), stabilize emulsions, act as a thixotropic thickening agent and suspending agent in gel and semi-solid preparations, form a transparent gel with components having similar refractive indices, and its viscosity is affected by the polarity of the liquid and the pH of the system. In non-inhalation aerosol preparations, it is often used to promote the suspension of particles, prevent the formation of hard precipitates, and reduce nozzle clogging. It can also be used as a disintegrant for tablets, an adsorbent dispersant for powders, and a viscosity-increasing agent for suppositories containing lipophilic matrices.
Routes of Administration
Oral, inhalation, transdermal, sublingual, vaginal
Safety
Widely used in oral and some topical preparations, generally considered non-toxic and non-irritating. However, intraperitoneal and subcutaneous injections may cause local tissue necrosis and granuloma, so silica is not suitable for injection. LD50 (rat, IV): 15mg/kg; LD50 (rat, oral): 3.16g/kg
Contraindications
Not compatible with Diethylstilbestrol
来源和准备
Prepared by gas-phase hydrolysis of chlorosilanes, for example, using silicon tetrachloride and burning it with hydrogen and oxygen flames at 1800℃.
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