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ZLSIL®-S60A chromatographic grade silica gel
创建于04.18
ZLSIL®-S60A chromatographic grade silica gel
—— Accurate separation, efficient purification and whole-process adaptation
In the core field of chromatographic separation technology, ZLSIL®-S60A chromatographic-grade silica gel stands out with its excellent pore design, surface chemical flexibility, and stability, making it an ideal choice for small molecule separation and purification. As a key material in pharmaceuticals, fine chemicals, and natural products industries, it not only meets the precise analytical needs at the laboratory level but also supports efficient purification for large-scale production, helping customers achieve qualitative leaps in research and development as well as production.
Core performance: redefine the standard of small molecule separation
1. Pore design for specialized small molecules
• 60A (6nm) exclusive aperture: customized for small molecules with molecular weight <2000 Da. Uniform pore structure avoids molecular exclusion effect, ensuring that polar/non-polar compounds (such as drug intermediates and natural product monomers) can enter the pore efficiently, achieving deep retention and accurate separation.
• High specific surface area (497 m²/g): Provides sufficient adsorption sites and improves the enrichment ability of trace components by 30%, especially suitable for the separation of trace components in complex systems (such as the purification of active ingredients below 0.1% in Chinese medicine extracts).
2. The surface chemistry is flexible to adapt to multiple modes of demand
• Primary silanol phase separation: without derivatization, alcohols, phenols, alkaloids and other strong polar substances can be separated directly through hydrogen bond and dipole action, and the mobile phase pH can be adjusted (2-8), so that peak shape optimization is more flexible.
• One-click switch between reverse phase / ion mode: by bonding C18, amino groups and other groups, it is easy to adapt to reverse phase chromatography (separating hydrophobic drugs) or ion exchange mode (purifying organic acids, nucleotides), a set of materials covering the entire range of polar separation requirements.
3. Both dynamic performance and stability are excellent
• Narrow particle size distribution (mainly 20-40μm): excellent permeability of the column bed, 20% improvement in column efficiency for analytical HPLC, 15% reduction in back pressure for preparative chromatography, and high throughput and high resolution.
• Low metal impurities (Fe³⁺≤0.02%): solve the tailing problem of alkaline compounds (such as amines and nucleosides) from the source, and achieve pharmacopoeia grade separation accuracy, suitable for the analysis of peptide drug impurities and other demanding scenarios.
Multi-application: covering the whole scene from R&D to production
1. Pharmaceutical industry: from impurity detection to active pharmaceutical ingredient purification
• Trace impurity analysis: HPLC accurate positioning of impurities below 0.1%, low metal contamination to ensure peak symmetry, and help API quality control.
• Chiral drug separation: After bonding chiral ligand, the separation degree of enantiomers such as omeprazole and paclitaxel is>1.5, which meets the requirements of optical purity detection and large-scale decomposition.
• Peptide / nucleoside purification: avoid irreversible adsorption of basic groups, yield increased by 10-15%, suitable for the production of high-end drugs such as insulin intermediates.
2. Fine chemicals: an efficient partner in synthesis reactions
• Reaction process monitoring: TLC can quickly locate the intermediate, HPLC can accurately quantify, and shorten the process optimization cycle; Suzuki The endpoint of coupling and amide formation can be judged more accurately.
• Isomer separation: the separation efficiency of para-xylene and phenolic positional isomers was improved by 25%, solving the problem of purification of structurally similar compounds.
3. Natural products: experts in the enrichment of active ingredients
• Direct separation of polar components: flavonoids, saponins, alkaloids and so on do not need complex pretreatment. In the positive mode, the components are enriched in a single injection, and the purification yield of artemisinin and catechin is more than 98%.
• Trace component capture: high specific surface area to enhance adsorption capacity, enrich μg level of active substances from plant essential oil and Marine biological extracts, and contribute to the development of innovative drugs.
4. Scale-up production: ideal packing material for chromatography
• Flash Chromatography adaptation: 40-63μm particle size model supports low pressure high flux separation, single batch processing capacity from milligram to gram free switching, strong equipment compatibility (Teledyne ISCO, Biotage, etc.).
• Industrial stability: pH 2-8 wide range of tolerance (bonding phase tolerance 1-12), can be regenerated by washing with common solvents such as methanol and dichloromethane, and the cost of consumables is reduced by 30%.
Technical indicators: strict quality control to achieve excellent performance
project | unit | standard | measured value | core value |
surface | - | White powder | accord with | The purity is intuitive and controllable, and there is no risk of impurity pollution |
Particle size qualification rate | % | ≥80 | 86 | Uniform particle distribution and consistent column efficiency |
Specific surface area (BET) | m²/g | 450-600 | 497 | Strong adsorption capacity, suitable for trace component separation |
Kongrong | ml/g | 0.6-0.8 | 0.73 | The pore structure is optimized and the mass transfer resistance is lower |
Metal impurities (Fe³⁺/Cl⁻) | % | ≤0.02 | reach the standard | The separation of alkaline compounds is free of tailing and the data are reliable |
loss on drying | wt.% | 3-5 | 3.93 | Low hygroscopicity and stable long-term storage performance |
Careful service: from packaging to application protection
• Packaging specifications: standard 20KG/bag, customized packaging is supported to meet the different scale requirements from laboratory pilot test to industrial production.
• Storage advice: Store in dry and ventilated environment, avoid moisture absorption or contact with volatile substances. The shelf life is up to 24 months, and the quality is consistent.
• Technical support: Provide coupling process guidance, chromatographic column filling scheme and customized solutions for difficult problems to help customers quickly establish separation methods.
Three reasons to choose ZLSIL®-S60A
✅ Specialized small molecules: 60A aperture + high specific surface area, the separation efficiency of compounds <2000 Da is increased by 40%;
✅ Mode is boundless: positive phase / reverse phase / ion exchange can be switched at will, and a set of materials covers all polar separation scenarios;
✅ Cost reduction and efficiency improvement: easy to activate regeneration, long storage cycle, and the cost of large-scale application is directly reduced by 25%.
Whether it is impurity analysis in drug development or large-scale purification in chemical production, ZLSIL®-S60A chromatographic silica gel has always been a reliable partner for your chromatographic separation with its stable performance and flexible adaptability.
For immediate consultation, get exclusive separation and purification solutions, so that every separation is accurate and controllable!
contact way: Tel: 053188737397 E-mail: levin@zhonglian-chem.com official website:www.zhonglian-chem.com |
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