loid® FP Pharmaceutical Silica: Amandla Okuxhumanisa Okugcwele Esikhathini Esisha Sokukhiqiza Imithi

Kwadalwa ngo 02.27

I-Syloid® FP Pharmaceutical Silica: Ukuvuselelwa Okugcwele Kwekusasa Elisha Lokukhiqiza Imithi

    
                        I-Syloid FP Silica Brochure - EU ver.pdf.pdf
                        723.06KB

Izici ezintsha ze-Syloid® FP Pharmaceutical Silica ekukhiqizeni imithi.

I-Syloid® FP series ye-silica yezemithi iyisithako sezokwelapha esisebenza ngezindlela eziningi esethulwe yiGrace. Iphule ngokuphelele indawo yezithako zendabuko njengezinto zokugcwalisa/zokucubungula ezingasebenzi. Ngokwakhiwa kwayo okuyingqayizivele okungalawulekayo kwe-mesoporous, ukuhlanzeka okuphezulu kakhulu, namazinga omhlaba wonke wokukhiqiza wezinga lezemithi, ingafinyelela imisebenzi eminingi ngesikhathi esisodwa njengokuthuthukisa ukuhamba, ukuvimbela ukunamathela, ukuvimbela umswakama, ukumunca, nokukhuthaza ukuncibilika, kuthuthukisa kakhulu ukusebenza kahle kokukhiqizwa kwezilondolozi, izinga lokuncibilika komuthi, ukuzinza kokugcina, kanye nokusebenza kahle kokwelapha. Ihambisana namazinga omhlaba wonke we-USP-NF, EP, kanye ne-JPE, futhi iphethe isitifiketi sokuqala se-IPEA excipient GMP embonini. Ingakusiza izinkampani zemithi ukuthi zifushane umjikelezo wokwethulwa komuthi omusha, yehlise izingozi zokuhlinzekwa kanye ne-R&D, futhi ilungele ukuthuthukiswa kwezilondolozi ezahlukahlukene ezifana nemithi emisha kanye nama-biosimilars, isebenza njengesithako esiyinhloko samasu ekuthuthukisweni kwezinhlelo zokudiliza imithi embonini yemithi.

I. Ukubekwa KweMikhiqizo Eyisisekelo kanye Nezindleko Zamasu

Izithasiselo zemithi ezijwayelekile zivame ukubhekwa njengezingxenye ezingasebenzi/izinsiza zokucubungula, kuyilapho uchungechunge lwe-Syloid® FP lwe-silica yemithi olwenziwe nguGrace lungumkhiqizo wezithasiselo zemithi onemisebenzi eminingi, ongakha inani eliyisisekelo kumabhizinisi emithi kusukela ezinyathelweni zokucwaninga, ukukhiqiza, kanye nezixhumanisi zokuthengisa:

1. Thuthukisa Inzuzo: Ukukhetha kahle le excipient kungathinta kakhulu ukusebenza kahle kokukhiqiza, izinga lokuphuma kwemithi, ukusebenza kahle kwezokwelapha, kanye nokuzinza kokwakhiwa, kuhambisana nokuthuthukiswa kwe-biosimilars, ukulungiselela okuxubile, njll. Ukungenelela kusenesikhathi ku-R&D kunganciphisa isikhathi sokwethulwa kwemithi emisha futhi kuthuthukise izinga lokuphumelela kokuhweba kwezinto ezintsha zamakhemikhali (NCEs) kanye nezinto ezintsha ze-biological (NBEs).

2. Nciphisa Izingozi Zokuxhumana Okugcwele: Kungagwema izingozi ezifana nokuphazamiseka kokuhlinzekwa, ukuphumelela kokuzinza kokwakhiwa, kanye nokwehluleka kwe-R&D kwemithi emisha okubangelwa yizinto eziphansi. Ukukhetha ama-excipients ahambisana nezimfuneko atholelwe imvume futhi akhiqizwe abakhiqizi abahamba phambili kunganciphisa amaphutha okusebenza, kuthuthukise ukuveza kahle kokuhlinzekwa, futhi kuhlangabezane nezidingo ze-R&D ze-Quality by Design (QbD).

II. Ukuhambisana Nokwaneliseka Kwekhwalithi Yomhlaba

1. Ukuhambisana Nezincwadi Zokwelapha Zomhlaba

Amazinga omhlaba wonke okuthobela kanye nokuqinisekiswa kwekhwalithi ekukhiqizeni imithi.

I-Syloid® FP silica ihambisana ngokuphelele nezindinganiso ezintathu ezinkulu zomhlaba wonke ze-pharmacopoeia futhi ingasekele ukubhaliswa kwemithi ezindaweni eziningi emhlabeni. Ulwazi oluthile lokuhambisana lungama:

Izinga le-Pharmacopoeia	Izinto Zokuhambisana Ezihambisanayo
I-United States Pharmacopeia - National Formulary (USP-NF)	Izidingo ezikhethekile zokuhlola i-silica
I-European Pharmacopoeia (EP)	Izidingo ezikhethekile zokuhlola i-colloidal hydrated silica
Izindinganiso Zokuhlanganiswa Kwe-Japanese Pharmacopoeia (JPE)	Izidingo ezikhethekile zokuhlola i-hydrated silica

2. Ukuqinisekiswa Okunembile kanye nohlelo Lokulawula Ikhwalithi

• I-Grace iyibhizinisi lokuqala emhlabeni ukuthola isitifiketi se-IPEA excipient GMP. Izindawo zayo zokukhiqiza ziphinde zadlula isitifiketi se-ISO 9001, zihambisana nemithetho ye-REACH, futhi zithola ukuthuthukiswa okuqhubekayo kwekhwalithi ngohlelo lwe-LEAN Six Sigma®.

• Isistimu yokuhlinzekwa ehambisana nomkhondo kuyo yonke indlela: UGrace wenza ukukhiqizwa efektri yoqobo, ulawula ngokuphelele ukugadwa kwesistimu yokuhlinzekwa, futhi uqinisekisa ukuzinza kokuhlinzekwa nokufana kwamaqoqo.

• Ukuhlelwa kokukhiqizwa komhlaba wonke: Imikhiqizo ikhiqizwa ezindaweni ezintathu ezinkulu: iWorms (eJalimane), iBaltimore (e-USA), kanye neSorocaba (eBrazil), iqinisekisa ukuhlinzekwa okuzinzile komhlaba wonke.

III. Ubuchwepheshe Obuyinhloko Nezici Zokwehlukanisa Umkhiqizo

Ubuchwepheshe obuyingqayizivele bokukhiqiza i-Syloid® FP Pharmaceutical Silica.

1. Ubuchwepheshe Bokukhiqiza Obuhamba Phambili Embonini

UGrace uyibhizinisi lokuqala emhlabeni ukwenza i-silica ibe yinto yokuhweba ngo-1921. Uchungechunge lwayo lwe-Syloid® FP lunezinhlelo zokukhiqiza ezikhethekile, ezakha izithiyo zobuchwepheshe eziyinhloko:

• Ukuklanywa okwenziwe ngokwezifiso kwesakhiwo esinezimbotshana ezincane: Inqubo yokukhiqiza ingalungisa izimpuphu ezincane ezinemidwebo yezimbotshana engalawuleka ngokunembayo. Ukwenza ngokwezifiso okuhlukahlukene kungafinyelelwa ngokulungisa ubukhulu bezimbotshana bangaphakathi, futhi inethiwekhi yezimbotshana ezincane eyenziwe iyisisekelo sokusebenza okuyinhloko komkhiqizo.

• Inqubo yokuhlanzwa ekhethekile: Isinyathelo esiyingqayizivele sokususa ama-ion amatshe asiza ukususa ubungozi bokungahambisani nemithi obubangelwa ama-ion amatshe, futhi kuthuthukisa kakhulu ukuhlanzeka komkhiqizo kanye nokuzinza kwezikhathi.

2. Amamodeli Omkhiqizo Oyinhloko Nemisebenzi Ekhethekile

Uchungechunge lwe-Syloid® FP lulungise amamodeli ahlukene ezinkingeni ezahlukene zokwakheka. Izici nezigameko zokusebenzisa amamodeli ayinhloko yilezi:

Imodeli Yomkhiqizo	Izici Eziyinhloko	Izimo Zokusebenzisa Eziyinhloko
Syloid® AL-1FP	Amandla Ahle Kakhulu Okulawula Ukufingqa	Protection of moisture-sensitive APIs, moisture-proof of hygroscopic materials, effervescent tablet formulations, moisture adsorption of capsules, and extension of product shelf life
Syloid® 244FP	Ultra-high porosity and adsorption capacity, capable of adsorbing 3 times its own weight in liquid	Ukwenza izinto ezingamanzi zibe yimpuphu, ukuthuthukisa ukuncibilika kwezidakamizwa ezingancibiliki kalula, ukukhuthaza ukuhlakazeka kwe-ODT, ukuvimbela ukunamathela kwe-enteric coating, kanye nokumunca amafutha/izinhlelo zamalipidi
Syloid® 72FP	Ukulungiswa okuhle kakhulu kwe-viscosity namakhono okuqinisa ukumiswa	Ukwenza ijeli izilungiselelo eziyiketshezi, ukuvimbela ukuhlukana ezinhlelweni zokumiswa, ukuqinisa izinto ezihambisa iphunga, nokuthuthukisa izilungiselelo ezifana nekrimu/ipasta

3. Izinzuzo Eziqhathaniswayo Zokusebenza Okuyinhloko

Uma kuqhathaniswa nemikhiqizo efanayo njenge-fumed silica, uchungechunge lwe-Syloid® FP lune-porosity ephezulu, indawo enkulu yangaphakathi eyenziwe nge-specific surface area, namandla amakhulu okumunca. Ingakwazi ukwenza imisebenzi eminingi ngesikhathi esisodwa, yehlise izinhlobo zezinto ezisetshenziswa ekwakhekeni, yenze lula inqubo yokukhiqiza, futhi yehlise izindleko ezibanzi.

IV. Izinzuzo Eziyinhloko Ekukhiqizeni Nokusebenza Kwemikhiqizo

1. Izinzuzo Eziyinhloko Ekukhiqizeni Nokwenziwa Kwezimboni

• Ukuthuthukiswa kwenqubo yempuphu: Kungathuthukisa ukuhamba kwempuphu ngaphansi kwezimo ezahlukene zomswakama wezinga eliphakathi, kungavumelana nenqubo yokuqondanisa ngqo, kuthuthukise ukushelela nokuhlanganiswa okufanayo, kunciphise inqubo yokuhlunga ngaphambi kokusebenzisa, futhi kugweme ukuvaleka komoya ngesikhathi sokukhiqiza.

• Ukuthuthukiswa kwekhwalithi yamaphilisi: Ukuqina kwamaphilisi kungathuthukiswa ngaphansi komfutho ophansi wokucindezela, kunciphise ubungozi bokwaphuka, ukugqashuka, nokubeka izendlalelo, futhi kunciphise izinga lamalotshi angagculisi.

• Ukuhambisana kokukhiqiza nokulawulwa kokulahlekelwa: Kunempahla ye-antistatic, kunciphisa ukulahlekelwa kwezinto ze-API; ukuminyana okuphezulu kwe-bulk kunciphisa ukukhiqizwa kothuli, kwenze kube lula ukuhlangabezana nezidingo zokuhambisana kwe-GMP, futhi konga isikhala ekugcinweni kwezinto.

2. Izinzuzo Eziyinhloko Ekusebenzeni Kwemikhiqizo

• Ukuthuthukiswa kokuzinza: Kungavikela ama-API abuthakathaka emswakeni, kuvimbele umswakama osendaweni ezungezile, kuvimbele ukumunca amanzi kwezinto ezimunca umswakama, kumunce uketshezi oluphuma ngesikhathi sokucindezela amaphilisi kanye nomswakama okhona kumagobolondo ekhasuli, futhi kuqinisekise ukuzinza kwesikhathi eside kwemikhiqizo lapho igcinwa.

• Ukuthuthukiswa kwe-bioavailability: Kungathuthukisa kakhulu ukumanziswa kanye nomugqa wokuncibilika kwemithi enokuncibilika kancane, kuxazulule inkinga eyinhloko embonini — njengamanje, 40% yemithi ethengiswayo kanye no-70% wama-API akuthuthukiswa anokuncibilika kancane. Lo mkhiqizo ungathuthukisa isivinini sokuncibilika komuthi ngokusebenzisa isakhiwo sawo esinemingqikithi, ngaleyo ndlela uthuthukise i-bioavailability.

• Ukuguquguquka kwemikhiqizo eminingi: Ingasetshenziswa njengomthwali wezinto zokwakha eziphilayo ukuze kufezwe ukwakheka kwepowder, umgibeli wezinhlelo zokuphakamisa uwoyela, umphikisi wokunamathela ezindaweni zokukh release, umphakeli wokufihla ukunambitheka, umphakeli wokulungiselela okudlula esikhunjeni, njll. Ilungele ukuthuthukiswa kwemikhiqizo ehlukahlukene ethuthukile efana nezinhlelo zokulungiselela eziphilayo- eziqinile, izinhlelo zokulungiselela eziphezulu zokulayisha imithi, kanye nezinhlelo zokulethwa kwemithi ezisekelwe ku-SEDDS.

V. Ucwaningo lwe-R&D kanye Nezixazululo Zokuxhumana Kwezimboni Zephelele

1. Ucwaningo oluqhubekayo lwe-R&D kanye Nokubambisana Kwecebo

• Iziqondiso ezizimele ze-R&D: Kufaka phakathi i-silica ehlelwe ngokwezifiso, izithasiselo ezithuthukisa ukuhamba, izithasiselo ezisebenzayo ezihlanganisiwe, ukulungiselela okuxubile, ubuchwepheshe bokukhululwa okuqhubekayo/okulawulwayo/okufakwe emathunjini, njll.

• Ukubambisana kwesu: Ukubambisana okujulile ne-Formac Pharmaceuticals, kuhambisana nepulatifomu yokuhlola ye-high-throughput ye-Formac nekhono le-Grace le-R&D ne-production ye-silica ukuze kuthuthukiswe ukuhlanganiswa kwe-silica-namakhambi okungcono kakhulu nokunqoba inkinga yezezimali yokutholakala kwemithi engahluziwe.

2. Izixazululo ze-Pharmaceutical ze-Grace ze-Chain Yezimboni Ephelele

I-Grace ingahlinzeka ngezixazululo eziphelele zokuhamba kwemithi kusukela ekutholeni imithi kuze kube ukufika emakethe, kufaka phakathi yonke imijikelezo ye-pharmaceutical:

1. Isigaba Sokuthola: I-Reveleris® Flash Chromatography Systems kanye ne-Grace® Silica Gels zisiza abacwaningi bezokwelapha ukuthi baqede ukuthuthukiswa kwe-NCE nokuhlanzwa ngokushesha.

2. Isigaba Sokuhlanganisa: Izakhiwo zamapeptide ezenziwe nge-Synthetech nezinto ezikhethekile zamalulwane zisekela ukuthuthukiswa kwezomtholampilo kanye nokukhiqizwa kwe-API.

3. Isigaba Sokuhlanzwa: Imidiya yokuhlanzwa ye-Davisil®, Vydac®, Amakholomu e-Spring® Chromatography, njll., ihlanganisa izidingo zokuhlanzwa kusukela kusayizi we-pilot kuya kusayizi wezimboni.

4. Isigaba Sokulethwa: I-Syloid® FP series pharmaceutical silica inika amandla ukuthuthukiswa kwefomula kanye nokuqanjwa kwezinhlelo zokulethwa kwezidakamizwa.

3. Ukuhlelwa Kwamasevisi Emhlabeni Wonke

UGrace usungule izindawo zobuchwepheshe nezokusebenza ezingxenyeni eziningi zomhlaba, okubalwa kuzo iChicago/Columbia (e-USA), iWorms (eJalimane), iShanghai (eShayina), iHyderabad (eNdiya), iLokeren (eBelgium), iRowville (e-Australia), njll., enikeza ukwesekwa kwezobuchwepheshe nezokuhweba okwenziwe ngendawo ezinkampanini zemithi zomhlaba wonke.

VI. Isitatimende Sokuhambisana

Onke idatha kuleli dokhumenti ivela ekuhlolweni kwangaphakathi kukaGrace kanye nolwazi olusebenzayo. Ngenxa yomehluko ezimweni zokusebenza zomsebenzisi, uGrace akawaqinisekisi imiphumela ehambisanayo; imininingwane yomkhiqizo namanani angashintsha ngaphandle kwesaziso sangaphambili. Wonke amagama okuhweba ahlobene angama-W. R. Grace & Co.-Conn. kanye nezinkampani ezingaphansi kwayo.

---

Imibuzo Ebalulekile Nezimpendulo Ezihambisanayo

Umbuzo 1 (Ubukhulu Besikhundla Samasu): Kungani i-Syloid® FP silica ingakwazi ukuphula isikhundla sezinto zokwelapha ezijwayelekile futhi ibe yithuluzi lamasu ezinkampani zemithi ekuthuthukisweni kwefomula?

Impendulo:

1. Ukuphumelela Okubalulekile Ezingeni Lokusebenza: Izithako eziningi zendabuko zenza umsebenzi owodwa oyisisekelo njengokugcwalisa nokushelela, kanti i-Syloid® FP silica ingakwazi ukwenza imisebenzi eminingi ngesikhathi esisodwa njengokushelela, ukuvimbela ukunamathelana, ukuvimbela umswakama, ukumunca, ukukhuthaza ukuncibilika, nokulungisa ubukhulu ngokusebenzisa isakhiwo sayo esingalawulekayo sezimbotshana. Inganciphisa izinhlobo zezithako ekwakhiweni, yenze lula inqubo yokukhiqiza, futhi yenze ngcono kakhulu ingqikithi yokwakheka kwezithako.

2. Ukunikezwa Amandla Okubalulekile Ngokuhamba Kwesikhathi Sokuphela Kokuphila: Lo okungeziwe kunganciphisa umjikelezo wokwethulwa komuthi omusha futhi kuthuthukise izinga lokuphumelela kwezentengiselwano kwe-NCEs/NBEs ekupheleni kwe-R&D; kuthuthukise ukusebenza kahle kokukhiqiza futhi kunciphise ukulahleka kwezinto kanye nezingozi zekhwalithi ekupheleni kokukhiqiza; kunwebe isikhathi sokugcinwa komkhiqizo futhi kuthuthukise umphumela wokwelapha womuthi ekupheleni kwemakethe. Kuhlanganisa ukudala inani kuyo yonke imijikelezo yokuphila yemithi, kunokuba kube nje impahla esizayo esixhumanisa ekukhiqizeni.

3. Isixazululo Esichazayo Ezinkingeni Eziyinhloko Embonini: Sihlose ubuhlungu obuqhubekayo bokutholakala kwezidakamizwa ezingancibiliki kalula embonini yemithi (40% yemithi ethengiswayo kanye no-70% wama-API akuthuthukiswa anokuncibilika okubuthakathaka), lo mkhiqizo ungathuthukisa kakhulu izinga lokuncibilika kwezidakamizwa nokutholakala kwazo. Ngaleso sikhathi, ufanele ukuthuthukiswa kwezinhlobo ezintsha ezifana nama-biosimilars, izinhlanganisela, nezinhlanganisela eziyimpahla eyisisekelo yezinhlelo zokudiliva izidakamizwa.

4. Ukuzivumelanisa Nokuthobela Okwe-R&D Yokubhalisa Yomhlaba Wonke: Umkhiqizo uhambisana namazinga amathathu amakhulu omhlaba wonke wezinkambiso zemithi futhi ubambe isitifiketi sokuqala se-IPEA excipient GMP embonini, esingahlangabezana nezidingo zesistimu ye-QbD R&D, kusiza izinkampani zemithi ukuthi zinciphise ubhaliso lomhlaba wonke kanye nezingozi zokuhlinzekwa, futhi kube ukukhetha okuyinhloko kwamasu okuthuthukiswa kwezinhlanganisela zomhlaba wonke.

Umbuzo 2 (Ubukhulu Bokulawula Ingozi): Yiziphi izici lapho izinkampani zemithi zinganciphisa khona izingozi enqenqeni yokuthuthukiswa nokuthengiswa kwemikhiqizo ngokukhetha i-Syloid® FP silica?

Impendulo:

1. Ukuncishiswa Kwezingozi Zokuhlinzekwa Nokuphepha Kokuhlinzekwa: Njengomkhiqizi wokuqala, iGrace iqonda ukuhlinzekwa okulandelelwe kuyo yonke isixhumanisi nokugadwa kuyo yonke inqubo, ngezindawo ezintathu zokukhiqiza emhlabeni wonke eJalimane, e-United States, naseBrazil. Kungagwema izingozi ezijwayelekile zama-excipients anezindleko eziphansi njengokuphazamiseka kokuhlinzekwa, ikhwalithi engazinzile yamaqoqo, nokuba nzima kokulandelelwa, kuqinisekiswe ukuqhubeka kokuhlinzekwa kokukhiqizwa kwemithi yokuthengisa.

2. Reduction of Compliance and Global Registration Risks: The product fully complies with the three major global mainstream pharmacopoeia standards of USP-NF, EP, and JPE. Its production bases have passed authoritative certifications such as ISO 9001 and IPEA excipient GMP. It is a mature pharmaceutical excipient approved globally, which can greatly reduce the compliance risks of pharmaceutical companies in global drug registration and shorten the regulatory review cycle.

3. Ukuncishiswa Kwezingozi Zokuthuthukiswa Kwefomula Nokuhluleka Kokusebenza: Umkhiqizo unendlela ekhethekile yokuhlanzwa, engasusa ama-ion amatshe asengadala ukusebenzisana kwezidakamizwa, ithuthukise ukuhlanzeka nokuvumelana kwamaqoqo, futhi igweme ingozi yokungahambisani phakathi kwezithako kanye nama-APIs. Ngaleso sikhathi, izakhiwo zawo ezizinzile zomzimba namakhemikhali zingaqinisekisa ukuzinza kwesikhathi eside kwefomula ekugcinweni, kugwenywe izingozi ezifana nokuhluleka kwefomula, ukuhluleka kwe-R&D, nokukhunjulwa ngemva kokuthengiswa okubangelwa izinkinga zezithako.

4. Ukunciphisa Ubungozi Bokukhiqiza Nokuhambisana Nekhwalithi: Umkhiqizo ungathuthukisa ukuhamba kwezimpophoma, unciphise uthuli nokulahleka kwe-API, futhi unciphise izinkinga zekhwalithi yokukhiqiza njengokuthamba/ukugqashuka/ukubeka izendlalelo kwamaphilisi, ngaleyo ndlela unciphise ubungozi bamaphutha okusebenza ekukhiqizeni kanye namazinga okungafaneleki kwamaloli. Isici esingenawo uthuli senza kube lula ukuhlangabezana nezidingo zokuhambisana nokukhiqiza kwe-GMP, kunciphisa izindleko zobungozi bekhwalithi nokuhambisana ekupheleni kokukhiqiza.

Umbuzo 3 (Ubukhulu Besicelo Sobuchwepheshe): Yiziphi izimo eziyinhloko zezicelo embonini yemithi ezifanele amamodeli ahlukene ochungechunge lwe-Syloid® FP silica, futhi yiziphi izinkinga ezithile zokwakheka abazixazululayo?

Impendulo:

Uchungechunge lwe-Syloid® FP luthuthukise amamodeli ahlukene ezinkingeni ezahlukene zokwakheka. Izimo zokuzivumelanisa nezixazululo zezinkinga zamamodeli ayinhloko yilezi:

1. Syloid® AL-1FP: Le yona ihlelwe njengemodeli ekhethekile yokulawula umswakama, igxile ekuxazululeni izinkinga ezihlobene noms Wakama ezifomeni. Ingavikela ama-API abuthakathaka emswakeni ekuhlanjululweni nasekwonakaleni, ivimbele ukumunca umswakama kwezinto ezimunca umswakama, imunce umswakama okhona kumagobolondo ekhasuli kanye noketshezi oluphuma ngesikhathi sokucindezela amaphilisi, futhi yehlise ukumunca umswakama kwezifome ezine-effervescent. Ixazulula ngokuyisisekelo izinkinga zokwehla kwefomula, ukufinyezwa kwesikhathi sokugcina, nokungabi namandla okwanele okubangelwa umswakama, iqinisekisa ukuzinza kwesikhathi eside kwezifome lapho zigcinwa.

2. Syloid® 244FP: Le isekelwe ikakhulukazi njengemodeli enekhono eliphakeme kakhulu lokumunca, elikwazi ukumunca izikhathi ezi-3 isisindo sayo esiwuketshezi, igxile ekuxazululeni izinkinga ezimbili eziyinhloko: ukuqina kwezinto zokusetshenziswa eziketshezi kanye nokuncibilika kwemithi engancibiliki kalula. Ingaguqulela ama-API aketshezi, amafutha, ukunambitheka, nezinye izinto zibe yimpuphu eqondile, iqede umthwalo ophezulu wemithi futhi ixazulule inkinga yomkhakha lapho izinto zokusetshenziswa eziketshezi kunzima ukuzilungiselela zibe izimiso eziqinile. Ngaleso sikhathi, ingathuthukisa kakhulu ukumanzi kwamaphilisi, ikhuthaze ukuhlakazeka okusheshayo kwe-ODT, ithuthukise isivinini sokuncibilika kanye ne-bioavailability yemithi engancibiliki kalula, futhi iphinde isebenze njengento yokuvimbela ukunamathela kwezendlalelo zokukhululwa kwe-enteric/sustained/controlled, ixazulule izinkinga ezifana nokunamathela kwamaphilisi nokungalingani kwezendlalelo ngesikhathi senqubo yokufaka izendlalelo.

3. Syloid® 72FP: Ibekwe njengemodeli yokulungisa ubukhulu nokuzinza kokumiswa, igxile ekuxazululeni izinkinga ezifana nokuhlukana, ukulawula ubukhulu, nokuntuleka kokuzinza kwemikhiqizo eyisihlanzi nemikhiqizo eyisigamu esiqinile. Ingaguqula izihlanzi zibe ama-gel acacile, ama-cream, noma ama-paste, ivumelane nentuthuko yemikhiqizo eyisigamu esiqinile nemikhiqizo edlula esikhunjeni. Ngaleso sikhathi, ingavimbela ukuhlukana kwezinto ezisistimu zokumiswa, izenze zizinzile izistimu zokumiswa kwamafutha, futhi izuze ukugcinwa okuzinzile kwezithako zamakha, ivumelane nezidingo zentuthuko zezinhlobo ezahlukene zezimiso ezifana nemikhiqizo eyisihlanzi, imikhiqizo yokuluma, nemikhiqizo yangaphandle.

Izindaba nolwazi olukhishwe yiZhonglian Chemical lunikezwa ngenhloso yokwazisa kuphela futhi luhloselwe kuphela ukubhekisela nokuxhumana phakathi kochwepheshe bemboni. Aluqinisekisi ukunemba nokuqedela kolwazi olunjalo. Akufanele usebenzise lolu lwazi ukufaka esikhundleni sokwahlulela kwakho okuzimele; ngakho-ke, uzobhekana nezingozi ezivela kunoma yikuphi ukusetshenziswa kolwazi, futhi iZhonglian Chemical ngeke ibe nesibopho. Uma kwenzeka kukhona ukwephulwa, sicela uxhumane nathi ukuze kususwe.

Contact

Leave your information and we will contact you.